antibacterial activity and cytotoxicity screening of sumatran kaduk (piper sarmentosum roxb)

phytochemical investigations of piper sarmentosum roxb., yielded four compounds; three amides, identified as 3-(3’,4’,5’-trimethoxyphenylpropanoyl) pyrrolidine, 3-(4’-methoxyphenylpropanoyl) pyrrole, n -(3-phenylpropanoyl) pyrrole and a sterol namely β -sitosterol . 3-(4’-methoxyphenylpropanoyl) pyrrole was found for the first time in this piper species. all chemical constituents were tested for their antibacterial activity using disk diffusion method and cytotoxicity screening using sul-forhodamine b (srb) assay. all of the compounds were found only active towards gram-positive bacteria except 3-(4’-methoxyphenylpropanoyl) pyrrole with no activity against both gram-positive and gram-negative bacteria. meanwhile, the cytotoxicity screening using srb assay indicated that none of these compounds was active as an anticancer agent.